Endocrine Abstracts

Glucocorticoid receptor (GR) is a ligand-dependent nuclear receptor which regulates the transcription of a wide spectrum of genes that are responsible for vital immunological, metabolic, developmental, and anti-inflammatory functions. GR transcriptional regulatory effects are modulated by co-regulators including the tetratricopeptide 5 (TTC5) which has been shown to stabilize GR and alter its action in response to cellular stress. TTC5 is a stress-responsive activator of p300 ...

Cofactors of the nuclear hormone receptors are crucial in regulating their transcriptional activity. The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily, involved in the regulation of metabolism, inflammation and stress–responses and many GR cofactors are known, including p300. Here, we identify a new cofactor for GR: TTC5/Strap, tetratricopeptide repeat domain 5/ stress–responsive activator of p300. Strap is a TPR motif containin...

Glucocorticoid hormones are used in the treatment of variety of diseases, due to their diverse range of effects. Acute lymphoblastic leukaemia (ALL), the most common form of childhood cancer, is one such disease treated by glucocorticoids (GCs). Although there has been much success in the treatment of ALL with GCs, drug resistance remains a problem, despite the detailed knowledge of the signalling networks underlying the GC actions through the glucocorticoid receptor (GR). Sys...

Glucocorticoids (GCs) have an important role in inflammation, apoptosis and immunosuppression and are among the most widely prescribed medications in clinical practice. GCs exert their effect by binding to the transcription factor, glucocorticoid receptor (GR). GCs are used in the treatment of acute lymphoblastic leukaemia (ALL) as they induce apoptosis in lymphoid cells, however resistance and side effects still occur frequently. Computational modeling has enormous potential ...